In late April 2025, the FDA issued a key update regarding the use of compounded GLP-1 receptor agonists like semaglutide and tirzepatide. The central message is that the agency is tightening oversight now that it is reporting that the national supply of FDA-approved GLP-1 drugs has stabilized. However, the information the FDA is relying on is incomplete, and it is likely that shortages of supply still exist in many areas and within many pharmacies.
Here’s the FDA’s stance in a nutshell:
- Compounded drugs are permitted when there is a bona fide shortage of the FDA-approved versions, and only under specific conditions, such as when the dosages or products are not commercially available, or for particular indications unique to an individual patient.
Translation for patients: Bulk manufacturing of compounded medication at approved dosages that are commercially available is no longer permitted. Compounded medications are still available for specific patients if the treating physician has recommended a compounded medication that is not commercially available to meet a particular patient’s needs.
Why Were Compounded GLP-1 Drugs So Popular?
GLP-1 receptor agonists—such as semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound)—work by mimicking hormones that regulate blood sugar, appetite, and digestion. Originally developed for diabetes, they have been shown to significantly aid in weight loss.
As their popularity surged, drug manufacturers struggled to keep up with demand, especially for Wegovy, the weight loss–specific formulation of semaglutide. In response, compounding pharmacies began creating alternative formulations for patients who couldn’t access or afford the name-brand versions.
What Does This Mean for Patients Currently Using Compounded Semaglutide?
If you’re currently taking a compounded version of semaglutide, here’s what to keep in mind:
- Your pharmacy may no longer be able to provide it. As the FDA removes semaglutide and tirzepatide from its drug shortage list, compounders will likely be required to halt production.
- You should discuss a transition plan with your provider. Whether that means switching to an FDA-approved version or exploring alternatives, it’s critical to make this change under medical supervision. Compounded medication may still be available if they fill a speicific individual patient need or dose that is not commercially available.
- Online compounding websites will probably either change the way they operate or cease to exist.
The Bigger Picture: The Future of Weight Loss Medications
The GLP-1 revolution isn’t slowing down anytime soon. As pharmaceutical companies ramp up production and new weight loss medications enter clinical trials, patients will likely have more options in the near future—not fewer.
That includes:
- New once-weekly or even once-monthly injectable treatments.
- Oral versions of semaglutide, like Rybelsus, which may become more popular as patients seek convenience.
- Emerging drugs that target additional metabolic pathways for even greater fat loss.
How We Can Help at Laser Lipo and Veins Center
At our practice, we’ve always taken a comprehensive and responsible approach to weight loss.
If you’ve been using compounded semaglutide or are just starting your journey with medical weight loss, we can help you:
- Evaluate your options as the FDA rules evolve.
- Combine weight loss medications with personalized lifestyle plans that include nutrition counseling, liposuction options, and long-term wellness strategies.
And if medications aren’t the right path for you? Our team can guide you through body contouring and fat reduction procedures that offer real results without the need for injectables.
Final Thoughts
With new weight loss treatments on the horizon, there’s never been a better time to seek a trusted provider who understands the full picture.
At Laser Lipo and Veins Center, we’re here to walk with you every step of the way—from FDA changes to lifestyle shifts, from semaglutide to liposuction and beyond.
Ready to discuss your weight loss options? Schedule a consultation today and let’s find the path that’s right for you.
