What the Latest FDA Ruling on Compounded GLP-1 Medications Means for Weight Loss Patients

Over the past two years, medications like Wegovy, Ozempic, and Mounjaro have revolutionized weight loss. As demand skyrocketed and supplies fell short, many patients turned to compounded versions of GLP-1 medications—especially semaglutide and tirzepatide—through specialized pharmacies. However, recent moves by the FDA are changing the landscape again.

If you’re one of the thousands of patients exploring medical weight loss using GLP-1 agonists—or if you’re already taking compounded semaglutide—this news directly affects you. Here’s what you need to know about the FDA’s latest clarification, what’s changing in the world of compounding pharmacies, and how we’re responding at the Laser Lipo and Veins Center to help our patients make informed, safe decisions.

What Changed? The FDA’s Clarification on Compounded GLP-1 Drugs

In late April 2025, the FDA issued a key update regarding the use of compounded GLP-1 receptor agonists like semaglutide and tirzepatide. The central message: the agency is tightening oversight now that they are reporting that the national supply of FDA-approved GLP-1 drugs has stabilized. However, the information the FDA is relying on is incomplete, and it is likely that shortages of supply still exist in many areas and within many pharmacies. 

Here’s the FDA’s stance in a nutshell:

• Compounded drugs are permitted when there is a bona fide shortage of the FDA-approved versions, and only under specific conditions, such as the dosages or products are not commercially available, or for specific indications unique to an individual patient. 

Translation for patients: The days of widely accessible compounded semaglutide may be coming to an end.

Why Were Compounded GLP-1 Drugs So Popular?

GLP-1 receptor agonists—such as semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound)—work by mimicking hormones that regulate blood sugar, appetite, and digestion. Originally developed for diabetes, they have been shown to significantly aid in weight loss.

As their popularity surged, drug manufacturers struggled to keep up with demand, especially for Wegovy, the weight loss–specific formulation of semaglutide. In response, compounding pharmacies began creating alternative formulations for patients who couldn’t access or afford the name-brand versions.

For some, compounded medications offered a more affordable or timely solution. However, this workaround was only legally permissible under the FDA’s drug shortage guidance—which is now changing.

What Does This Mean for Patients Currently Using Compounded Semaglutide?

If you’re currently taking a compounded version of semaglutide, here’s what to keep in mind:

• Your pharmacy may no longer be able to provide it. As the FDA removes semaglutide and tirzepatide from its drug shortage list, compounders will likely be required to halt production.
  
• You should discuss a transition plan with your provider. Whether that means switching to an FDA-approved version or exploring alternatives, it’s critical to make this change under medical supervision.
  
• Online compounding websites will probably either change the way they operate or cease to exist.
  

At the Laser Lipo and Veins Center, we’re helping our patients navigate these transitions safely and effectively.

Is This a Bad Thing? Not Necessarily.

The return of a stable national supply of FDA-approved GLP-1 medications is great news overall. It means:

• The few insured patients with coverage for these medications for weight loss have access to consistent, regulated formulations.
• The weight loss field continues to evolve, with more options likely to come.
  

However, the loss of compounded alternatives may leave some patients feeling stuck—especially those who’ve had success with those formulations or relied on them for cost reasons.

What Are the Risks of Compounded GLP-1s?

The FDA’s increased scrutiny is rooted in safety concerns. Not all compounded versions of semaglutide and tirzepatide are created equal. Some of the risks include:

• Incorrect dosage: Inconsistent preparation can lead to underdosing or overdosing.
  
• Toxic impurities: Some compounds may use semaglutide sodium or other research chemicals not intended for human use.
  
• Lack of oversight: Compounded drugs are not subject to the same rigorous testing and FDA approval as branded drugs.
  

While many reputable compounding pharmacies follow strict standards, the recent surge in demand has attracted less reputable actors to the market.

The Bigger Picture: The Future of Weight Loss Medications

The GLP-1 revolution isn’t slowing down anytime soon. As pharmaceutical companies ramp up production and new weight loss medications enter clinical trials, patients will likely have more options in the near future—not fewer.

That includes:

• New once-weekly or even once-monthly injectable treatments.
• Oral versions of semaglutide, like Rybelsus, which may become more popular as patients seek convenience.
• Emerging drugs that target additional metabolic pathways for even greater fat loss.
  

How We Can Help at Laser Lipo and Veins Center

At our practice, we’ve always taken a comprehensive and responsible approach to weight loss.

If you’ve been using compounded semaglutide or are just starting your journey with medical weight loss, we can help you:

• Evaluate your options as the FDA rules evolve.
  
• Combine weight loss medications with personalized lifestyle plans that include nutrition counseling, liposuction options, and long-term wellness strategies.
  

And if medications aren’t the right path for you? Our team can guide you through body contouring and fat reduction procedures that offer real results without the need for injectables.

Final Thoughts

While the end of widespread compounded GLP-1 medications might feel like a loss for some patients, it ultimately signals a return to safer, more reliable care. With new weight loss treatments on the horizon, there’s never been a better time to seek a trusted provider who understands the full picture.

At Laser Lipo and Veins Center, we’re here to walk with you every step of the way—from FDA changes to lifestyle shifts, from semaglutide to liposuction and beyond.

Ready to discuss your weight loss options? Schedule a consultation today and let’s find the path that’s right for you.